Complete control of cardiovascular health with Vitamin C in the obese – Nature World Report

Heart problems can now be set aside as researchers find that those who are obese can consume vitamin C supplements and derive the same benefits as regular exercise. The study suggests that obese people can keep their cardiovascular health under control even without regular exercising routine.

Linus Pauling says, “I think we can get almost complete control of cardiovascular disease, heart attacks and strokes by the proper use of (vitamin C and lysine) … even cure it.”

A meta-analysis of 44 clinical trials has shown a significant positive effect of vitamin C on endothelial function when taken at doses greater than 500 mg per day. The researchers noted that the effect of vitamin C supplementation appeared to be dependent on health status, with stronger effects in those at higher cardiovascular disease risk.

Caitlin Dow, PhD, postdoctoral research fellow at the University of Colorado, Boulder, the lead author of this study, conducted to analyze if vitamin C supplements can also lower endothelin-1 activity. Previous studies have shown that Vitamin C supplements improve vessel function as well.

Scientists explained that exercise is proven to reduce endothelin-1 activity, however, doing it on a daily basis may not be easy for most overweight people. Another study confirmed that vitamin C consumption can decrease the risk of people with asthma developing exercise-induced bronchoconstriction.

35 overweight adults were a part of this study and researchers compared the effects of vitamin C and exercise on the protein known as endothelin-1, which has a constricting action on small blood vessels. Some of them were given vitamin C supplements and the others were made to exercise daily.

The blood vessels of overweight and obese people showed elevated activity of the protein, ET-1. Those vessels with high ET-1 activity are more prone to constricting. This narrowing can mean blood vessels are less responsive to the changing demands on blood flow, therefore increasing a the risk of vascular disease.

Researchers observed that in both cases – daily exercisers and vitamin C takers – vasoconstriction to endothelin-1 increased two times. Results showed that daily supplementation of vitamin C at a time-release dose of 500 mg daily reduced endothelin-1-mediated vessel constriction as much as walking did.

The protein activity increases in overweight people at night because of this high endothelin-1 activity, small vessels are more prone to constricting. This results in the blood vessels becoming less responsive to blood flow demand with an increase in the risk of vascular disease.

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