Of all the recent discoveries made through the latest cancer research, this one may be the most significant. Indeed, a new study says that an incomparable amount of vitamin C could put a stop to tumor growth in those suffering from colorectal cancer.
In a statement regarding the research, scientists report “Several ongoing clinical studies are exploring whether a therapeutic effect may require a high plasma level of vitamin C that can be achieved only by intravenous, not oral, administration.”
Oral application of the treatment, of course, renders the medicine (in this case, vitamin C) vulnerable to breaking down from the process of digestion. Intravenous application is generally better for most medicines because it delivers the medicine directly into the blood stream. But for this study, this is new information so much of the details are still uncertain.
The statement continues, “In the meantime, the molecular mechanism by which vitamin C might selectively kill cancer cells remain unclear.”
In addition, their statement also says, “In this study, Jihye Yun and colleagues studied human colorectal cancer (CRC) cells with certain mutations in genes known as KRAS and BRAF, which regulate cell growth. They show that these cells take up the oxidized form of vitamin C through a certain receptor that is specifically over-expressed in the mutant cells. This leads to oxidative stress, which in turn inactivates an enzyme required for growth of mutant but not normal cells.”
And in conclusion, the agency notes: “Consistent with the cell culture results, the authors found that administration of high-dose vitamin C to mice bearing intestinal tumors with the KRAS mutation inhibited tumor growth. Moving forward, scientists can begin to explore whether the selective toxicity of vitamin C to these cells could be exploited to create vitamin C-based therapies.”