High dose of vitamin C can kill colorectal cancer cells (+Video) – Nature World Report

Vitamin C is known to be an effective component in the the treatment of some diseases and it regulates the body’s key functions too. New findings come with a promise for novel cancer therapy.

Abram Hoffer, M.D., Ph.D says in an older research that administering vitamin C is an important part of any cancer treatment program. One important point that had cropped up in trials was that giving large amounts of Vitamin B3, along with vitamin C, to patients on cancer treatment program, regardless of their diagnosis, tended to do very well.

However, it is still not known as to how the molecular mechanism works using which Vitamin C may demolish mutated colorectal cancer cells.

Many clinical trials are in progress trying to find if a therapeutic effect may need a increased plasma level of Ascorbic Acid, which can be attained by simple intravenous administration instead of an oral one.

WebMD reports, Vitamin C is an essential vitamin and humans must get this from food products like fruits and vegetables. However, some animals have the ability to make it on their own. Citrus fruits are a rich source of Vitamin C.

Earlier studies also confirmed that high dose vitamin c improves chemotherapy in treating cancer. (Eatch Video for the same)

National Cancer Institute reports that vitamin C in high dose has been analyzed as a cancer treatment for patients since the 1970s. Clinical trials suggest that higher doses of vitamin C could actually play a role in slowing down the growth and spread of colon, liver, prostate, pancreatic, and many different kinds of cancer.

It sounds amazing that a deadly disease like cancer may get a novel therapy using Vitamin C but earlier research in this field have proved to be unpleasant. Several clinical studies have been done but no prominent outcome has been achieved.

Earlier findings by Professor Margreet Vissers from Centre for Free Radical Research stated that biological functions of Vitamin C are significant in cancer treatment and investigations about the contribution of ascorbate to cancer growth as a result of its co-factor activity for these enzymes were underway.

Dr. Lewis Cantley of Weill Cornel Medicine in New York led a team of researchers and discovered that giving a high dose of Vitamin C may demolish the colorectal cancer.

Jihye Yun and colleagues further analyzed the nature of colorectal cancer (CRC) cells in humans that reveal some mutations in genes termed as KRAS and BRAF. These two genes are responsible for cell growth. Researchers show that these cells pick oxidized version of Vitamin C via a receptor which is over-expressed particularly in colorectal cancer cells with mutations.

This further results in oxidative stress and ultimately inactivates an enzyme that is needed for assisting in mutant cancer cell growth but avoiding normal cells. These findings are also in line with the cell culture results where researchers discovered that high Vitamin C dose given to mice suffering from colorectal cancer with the KRAS mutation also stopped cancer growth.

Based on this study, researchers may start to find if this reaction of vitamin C to mutant cancer cells could be further used to develop therapies based of high Vitamin C dose.

Source: EurekAlert Press Release

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