The recent findings sure seem promising for the possible development of effective cancer therapy but this does not mean that drinking orange juice would immediately Ascorbic Acid or Vitamin C is known to be an effective component in the the treatment of some diseases and it regulates the body’s key functions too.
High dose of Vitamin C targets and kills cancer cells
Latest findings show that Vitamin C may effectively kill colorectal cancer cells having mutations if administered in high doses.
It sounds amazing that a deadly disease like cancer may get a novel therapy using Vitamin C but earlier research in this field have proved to be unpleasant. Several clinical studies have been done but no prominent outcome has been achieved.
Scientists claim that the factor that kills colorectal cancer cells with mutations is the unusual manner in which vitamin C deals with these cells resulting in their elimination. Findings of the study have been published in the magazine Science.
Clinical trials suggest that higher doses of vitamin C could actually play a role in slowing down the growth and spread of colon, liver, prostate, pancreatic, and many different kinds of cancer. National Cancer Institute reports that vitamin C in high dose has been analyzed as a cancer treatment for patients since the 1970s.
At present too, many clinical trials are in progress trying to find if a therapeutic effect may need a increased plasma level of Ascorbic Acid, which can be attained by simple intravenous administration instead of an oral one. However, it is still not known as to how the molecular mechanism works using which Vitamin C may demolish mutated colorectal cancer cells.
WebMD reports, Vitamin C is an essential vitamin and humans must get this from food products like fruits and vegetables. However, some animals have the ability to make it on their own. Citrus fruits are a rich source of Vitamin C.
Dr. Lewis Cantley of Weill Cornel Medicine in New York led a team of researchers and discovered that giving a high dose of Vitamin C may demolish the colorectal cancer.
Jihye Yun and colleagues further analyzed the nature of colorectal cancer (CRC) cells in humans that reveal some mutations in genes termed as KRAS and BRAF. These two genes are responsible for cell growth. Researchers show that these cells pick oxidized version of Vitamin C via a receptor which is over-expressed particularly in colorectal cancer cells with mutations.
This further results in oxidative stress and ultimately inactivates an enzyme that is needed for assisting in mutant cancer cell growth but avoiding normal cells. These findings are also in line with the cell culture results where researchers discovered that high Vitamin C dose given to mice suffering from colorectal cancer with the KRAS mutation also stopped cancer growth.
Based on this study, researchers may start to find if this reaction of vitamin C to mutant cancer cells could be further used to develop therapies based of high Vitamin C dose.
High Dose of Vitamin C into the body kills cancer cells
Vitamin C may one day be harnessed in order to fight colorectal cancer as per a new study. This study also stipulated the people who could get the drug and the one who shouldn’t.
The insights may have implications for other cancers as well which have high GLUT1 transporter levels like renal cell carcinoma, pancreatic cancer and bladder cancer. The main area which needs to be investigated is of the effects which DHA could have on regular cells when they are absorbed by the human body in high amounts.
The dosing recommendations haven’t been determined yet either. Studies later revealed that vitamins need to be intravenously administered in order to provide a dosage which was high enough for eliminating cancer cells. Recent clinical trials that were conducted on humans for testing toxicity showed that the intravenous vitamin C infusion at a dose which is converted to a similar level as the mice trials which had proper safety profiles. But, a few researchers believe vitamin C therapy can be helpful combined with other cancer treatments such as radiation or chemotherapy.
Even though these findings have been quite encouraging, scientists have said that there is lots more research required to turn this knowledge into an effective course of treatment for colorectal cancer since there is a lot of information they don’t have on reactions of DHA.
Scientists have already known that there is a specific membrane protein called glucose transporter GLUT1 which enables DHA and glucose to enter our cells but ascorbic acid can’t do so. Earlier research has examined vitamin C effects during cancer treatment since the 70s and results are usually contradictory.
This study has shown that DHA is a Trojan horse. But, the natural antioxidants can diminish and cause the cell to die because of oxidative stress. The reaction is more important since KRAS and BRAF mutant cells need lots of antioxidants to survive. These characteristics make the cells vulnerable to DHA.
Vitamin C may prove to be quite effective when it comes to treating cancer
It seems great a deadly disease such as cancer may just get a treatment therapy that involves the use of Vitamin C but research that was conducted in this field earlier has proven to be quite unpleasant. Vitamin C is also known as ascorbic acid and it’s an important nutrient which is required by our body for its natural development. There are some smaller trials which have been conducted in the last five years for pancreatic cancer and ovarian cancer which hinted that vitamin C treatments combined with chemotherapy may extend survival for cancer patients.
Vitamin C’s power may just get harnessed one day for fighting colorectal cancer as per this new study.
As per this report, researchers reached the conclusion when they found that a large amount of vitamin C, same as the amount found in three-hundred oranges was able to weaken and kill mutated KRAS and BRAF genes in mice. The main thing found here is that Vitamin C can be effective in killing tumor cells which carry the mutation know for causing cancer. The findings are even in line with cell culture results in which researchers have discovered high vitamin C doses given to mice that had colorectal cancer and the KRAS mutation was able to stop the growth of cancer as well. DHA is basically a form of vitamin C which is created during the process of oxidation.
But the researchers were positive the discovery will help develop treatments for colorectal cancer that has its roots in KRAS and BRAF mutant cells. Apart from glucose, GLUT1 can also deliver DHA (dehydroascorbic acid) to these cells.
The study has also shown that DHA is a sort of Trojan horse. Once it enters, the natural antioxidants in cancer cells tries converting DHA back into ascorbic acid and during the process, the antioxidants get depleted and the cell then dies dues to oxidative stress.
Presently, there are a number of clinical trials which are being conducted to find if there is a therapeutic effect that requires increased levels of ascorbic acid which can easily be attained through intravenous administration.
Vitamin C could target a few common cancers
Now, new research suggests that Vitamin C may also aid in the fight against cancer, particularly colorectal cancer. However, a few other researchers still believe that vitamin C therapy may be helpful in combination with other standard cancer treatments like chemotherapy or radiation.
These findings are also in line with the cell culture results where researchers discovered that high Vitamin C dose given to mice suffering from colorectal cancer with the KRAS mutation also stopped cancer growth. The findings could lead to the development of new treatments and provide critical insights into who would most benefit from them. DHA is a form of Vitamin C resulted from an oxidation process. Furthermore, the researchers emphasized that since BRAF and KRAS mutant cells require a lot of antioxidants to survive, the effect of DHA on the said cells are greater.
This study has shown that DHA is a Trojan horse. However, instead of doing so, the natural antioxidants diminish eventually causing the cell to die due to “oxidative stress”. KRAS and BRAF mutated colon cancer cells were targeted with the oxidized form of Vitamin C. Thus free radicals found the way to metabolize the glucose in the cells, starving them to death. KRAS- and BRAF-mutant cells also produce more reactive oxygen species than normal cells, and so they need more antioxidants in order to survive. In this study, Jihye Yun and colleagues studied human colorectal cancer (CRC) cells with certain mutations in genes known as KRAS and BRAF, which regulate cell growth.
The investigators say their study could lead to the development of new biomarkers that could help physicians determine who would most benefit from treatment. These insights may also have implications for other hard-to-treat cancers that express high levels of GLUT1 transporter, such as renal cell carcinoma, bladder cancer and pancreatic cancer. “Further study is definitely needed to expand our understanding of these processes”.
Dr. Lewis Cantley of Weill Cornel Medicine in New York led a team of researchers and discovered that giving a high dose of Vitamin C may demolish the colorectal cancer. “This is not a therapy that you would want to wander into blindly without knowledge of what is going on in your tumor”, Cantley added. The dosing recommendations haven’t been determined yet either. Nobel Laureate Linus Pauling was sidelined by the medical world after she had championed the idea of vitamin C being able to combat several illnesses including cancer. Moving forward, scientists can begin to explore whether the selective toxicity of vitamin C to these cells could be exploited to create vitamin C-based therapies.