Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in … – Dove Medical Press

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Authors Xia Z, Hu YZ, Han ZT, Gao Y, Bai J, He Y, Zhao H, Zhang H

Received 6 July 2017

Accepted for publication 6 September 2017

Published 10 October 2017
Volume 2017:12
Pages 1673—1679

DOI https://doi.org/10.2147/CIA.S145700

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication:
Professor Zhi-Ying Wu

Zheng Xia,^1,* Yazhuo Hu,^1,* Zhitao Han,¹ Ya Gao,¹ Jie Bai,² Yao He,¹ Hua Zhao,³ Honghong Zhang¹

¹Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics, ²Cinical Laboratory in South Building, Chinese PLA General Hospital & Chinese PLA Medical Academy, Beijing, China; ³Zhantansi Outpatient Department, Chinese PLA 309 Hospital, Beijing, China

^*These authors contributed equally to this work

Background: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China.
Methods: A total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing. The frequency and distribution of the SNPs were compared between cases and controls.
Results: The distribution of genotypes of VDR-FokI was significantly different between the control and DM group (P=0.033), as well as between the control and DH subgroup (P=0.011) but not DO subgroup (P=0.111). The frequency of C allele and CC genotype of FokI was significantly higher in the DH patients than in the controls (P=0.015 and P=0.003, respectively). Logistic regression analysis in a dominant model homozygous for the C allele of the FokI SNP showed that CC genotype was associated with DH patients (OR =1.797, 95% CI: 1.077–2.999, P=0.025). Significant associations of the ApaI and TaqI SNPs with either DO or DH subjects were not observed.
Conclusion: These findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China.

Keywords: vitamin D receptor, VDR, diabetes, dyslipidemia, polymorphism, elderly

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