Low vitamin D levels predict ED in diabetics – ProHealth

Reprinted with the kind permission of Life Extension.

October 2 2017. An article published on September 23, 2017 in The Aging Male reveals an association between decreased serum vitamin D levels and a greater risk of erectile dysfunction (ED) in diabetics.

“The present study is the first study demonstrating the higher rate of ED in diabetic male patients with vitamin D deficiency,” announce authors Sema Basat and colleagues.

The study included 98 diabetic men between the ages of 18 and 80 years. International Index of Erectile Function (IIEF-5) questionnaire scores determined the presence and severity of ED, with higher scores indicative of no ED. Among the 77 participants with the condition, 45 had moderate ED and 32 had severe ED. Blood samples were analyzed for 25-hydroxyvitamin D levels [25(OH)D], hormones and other factors.

A moderate correlation was observed between increased vitamin D levels and higher IIEF scores, particularly among those between the ages of 45 and 65 years of age. Men whose IIEF-5 scores were indicative of severe ED had vitamin D levels that averaged only 10.51 nanograms per milliliter, which was significantly lower than the average levels of participants with no or moderate ED.

“There is a significant relationship between 25(OH)D deficiency and ED in male patients with type 2 diabetes mellitus,” the authors write. “This relationship is considered to be mediated by increased nitric oxide production by 25(OH)D in endothelial cells through various pathways, inhibition of apoptosis and prevention of endothelial dysfunction by preventing against oxidative stress. In conclusion, 25(OH)D levels are correlated with ED scores especially in men with type 2 diabetes mellitus aged between 45–65 years.”


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