The study is curial information because it shows guidance to men and their doctors who may be considering active surveillance, in which they monitor the cancer rather than remove the prostate.According to study Vitamin D taking linked to Prostate cancer.
Discovering link between aggressive forms of Prostate cancer and the lack of vitamin D
Since cancer is actually a whole bunch of disease, each affecting the body in different ways, you can’t really “find the cure for cancer”. So, a few medical teams decided to work a different angle. Instead of trying to look for cures, the team is instead looking for what causes cancer in the first place.
Aggressive prostate cancer is defined by whether the cancer has migrated outside of the prostate and by a high Gleason score — used to help evaluate the prognosis of men with prostate cancer.
Noticing a relationship between aggressive forms of prostate cancer and the lack of vitamin D, the team of researchers from the Northwestern University Feinberg School of Medicine decided to perform a study in order find the association and hopefully learn more about the fatal disease.
By using a smaller sample from a larger study in the Chicago area examining the link between prostate cancer and vitamin D, the scientists looked at a total of 190 men out of the original sample of 1,760. The average age of the participants was 64, and they had all underwent a prostatectomy sometime between 2009 and 2014.
Out of the 190 subjects, 87 of them had suffered from aggressive prostate cancer. Confirming the researchers’ theories, they also had levels of vitamin D far lower than the recommended average of more than 30 nanograms per milliliter. Instead, the participants suffering from the aggressive form of cancer had somewhere around 22.7 nanograms per milliliter. Now, the researchers knew that vitamin D deficiency is linked to aggressive prostate cancer.
The study was part of a larger ongoing study of 1,760 men in the Chicago area examining vitamin D and prostate cancer. The current study included 190 men, average age of 64, who underwent a radical prostatectomy to remove their prostate from 2009 to 2014.
Having their theory confirmed, the team went on to explain why knowing this was so important. According to them, this is a very significant indicator that vitamin D deficiency can be used as a prediction tool for determining cases of aggressive prostate cancer.
Aggressive prostate cancer is defined by whether the cancer has migrated outside of the prostate and by a high Gleason score. A low Gleason score means the cancer tissue is similar to normal prostate tissue and less likely to spread; a high one means the cancer tissue is very different from normal and more likely to spread.
Even further, vitamin D may even be a biomarker for the levels of aggressiveness of prostate cancer. It was already known that vitamin D could predict bone health, as well as the aggressiveness of other diseases, so now that we know that it also predicts how aggressive prostate cancer is, men will know how important it is to replenish their vitamin D levels.
Lack of vitamin is particularly an issue in this day and age. With so many people working office jobs, with the need for overtimes raising, and with the fluctuating economy, many people can’t really afford spending time at the beach or buying supplements to bring their vitamin D levels back to normal.
If you’re taking supplements to achieve adequate vitamin D levels, the Institute of Medicine recommends 600 international units of vitamin D per day. Murphy recommends people in areas experiencing long winters with low sunlight levels get 1,000 to 2,000 international units per day.
According to the American Cancer Society, approximately one men in seven is diagnosed with prostate cancer throughout his lifetime
Of that group, 87 men had aggressive prostate cancer. Those with aggressive cancer had a median level of 22.7 nanograms per milliliter of vitamin D, significantly below the normal level of more than 30 nanograms/milliliter. The average D level in Chicago during the winter is about 25 nanograms/milliliter, Murphy noted.
Most people in Chicago should be on D supplements, particularly during winter months, Murphy said.
“It’s very hard to have normal levels when you work in an office every day and because of our long winter,” he said. The Institute of Medicine recommends 600 international units of D per day, but Murphy recommends Chicago residents get 1,000 to 2,000 international units per day.
In the US, prostate cancer is the most common non-skin cancer in men. According to the Centers for Disease Control and Prevention (CDC), in most cases, prostate cancer grows slowly and does not cause a health problem.
The prostate specific antigen (PSA) test may show that there is a problem in the prostate, but it can also be high for other reasons.
The CDC urge men to take time to decide before seeking a PSA test or treatment for prostate cancer. Possible side effects of treatment include impotence, loss of bladder control and bowel problems.