Vitamin D Blog: Levels Severely Deficient in ARDS Patients – MedPage Today
Vitamin D deficiency has been linked to more than a few diseases, and the latest is acute respiratory distress syndrome (ARDS).
Deficiency was widespread say researchers after looking at more than 100 patients with, or at risk of getting, ARDS. And using mouse models, they also concluded that vitamin D deficiency appears to contribute to the development of ARDS. They published their findings on April 22 in Thorax.
“Taken together, these data suggest that vitamin D deficiency is ubiquitous in patients with ARDS and relates to adverse outcome,” wrote the researchers, who were led by Rachel Dancer, of the School of Clinical and Experimental Medicine at the University of Birmingham in the U.K. “We suggest that clinical strategies should be developed to replete vitamin D levels in patients at risk of ARDS and this approach might also have value as a treatment for established ARDS.”
All of the 55 patients in the study with ARDS were vitamin D deficient (defined as <50 nmol/L), found the researchers. They also looked at 57 esophagectomy patients who were at risk of getting ARDS and found that 55 of them (96%) were deficient before the operation, though their levels were still significantly higher than those with ARDS (85 pmol/L versus 35.5 pmol/L; P=0.0001).
A small, third cohort was also included: 8 patients who were undergoing esophagectomy who’d received high-dose supplementation of vitamin D prior to their surgery.
For the mouse models, researchers allowed one group to become vitamin-D deficient by the diet they gave them. They found that the deficient mice had increased evidence of alveolar epithelial damage, said the authors. “Mice that were vitamin D deficient became more hypoxic, suggesting physiologically worse lung injury,” they added.
Limitations of the study included the fact that researchers couldn’t be certain from the blood samples of ARDS patients if low vitamin D levels were there before the onset of the condition, or if they fell because of the onset of ARDS. Also, the data collected from the at-risk group were divided because of disparities in deficiency, and the data needs validating in another cohort, according to the researchers.
Other posts from the Vitamin D Blog:
- Vit D Roundup: Athletes Come Up Short, Tumor Growth Slowed
- Vit D Linked With Depression in Women
- Extremes Tied to Greater Cardiovascular Risk
- Op-Ed Urges Supplement Skepticism
Have a tip on a vitamin D study? Email Parker Brown at firstname.lastname@example.org, or catch our vitamin D feed on Twitter, @vitaminDblog.
Researchers disclosed no relevant relationships with industry.