Back to Browse Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Authors Odler B, Ivancsó I, Somogyi V, Benke K, Tamási L, Gálffy G, Szalay B, Müller V

Published Date September 2015 Volume 2015:10(1) Pages 2017—2025


Received 2 July 2015, Accepted 18 August 2015, Published 24 September 2015

Peer reviewers approved by Dr Hsiao-Chi Chuang

Approved for publication by Dr Richard Russell

Balázs Odler,1 István Ivancsó,1 Vivien Somogyi,1 Kálmán Benke,2 Lilla Tamási,1 Gabriella Gálffy,1 Balázs Szalay,3 Veronika Müller1

1Department of Pulmonology, 2Heart and Vascular Centre, 3Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary

Introduction: The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma–COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown.
Aim: Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters.
Methods: A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients.
Results: The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86±1.79 ng/mL and 14.27±1.88 ng/mL vs 25.66±1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group.
Conclusion: Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.

Keywords: ACOS, obstructive lung disease, CAT

Download Article [PDF] 

Creative Commons License
This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License.
The full terms of the License are available at
Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
Permissions beyond the scope of the License are administered by Dove Medical Press Limited.
Information on how to request permission may be found at:

Readers of this article also read:

First-time admissions for opioid treatment: cross-sectional and descriptive study of new opioid users seeking treatment

Flórez G, López-Durán A, Triñanes Y, Osorio J, Fraga J, Fernández JM, Becoña E, Arrojo M

Neuropsychiatric Disease and Treatment 2015, 11:2431-2440

Published Date: 24 September 2015

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Bruun J, Larsen TB, Jølck RI, Eliasen R, Holm R, Gjetting T, Andresen TL

International Journal of Nanomedicine 2015, 10:5995-6008

Published Date: 24 September 2015

Peer supporter experiences of home visits for people with HIV infection

Lee HJ, Moneyham L, Kang HS, Kim KS

HIV/AIDS – Research and Palliative Care 2015, 7:233-239

Published Date: 24 September 2015

Mapping of dendritic lesions in patients with herpes simplex keratitis using in vivo confocal microscopy

Yokogawa H, Kobayashi A, Mori N, Sugiyama K

Clinical Ophthalmology 2015, 9:1771-1777

Published Date: 24 September 2015