Taking a high dose of vitamin D3 is safe for people with multiple sclerosis (MS) and may help regulate the body’s hyperactive immune response, according to a pilot study published in the medical journal of the American Academy of Neurology.
“These results are exciting, as vitamin D has the potential to be an inexpensive, safe and convenient treatment for people with MS,” says study author Peter Calabresi, M.D.
“More research is needed to confirm these findings with larger groups of people and to help us understand the mechanisms for these effects, but the results are promising.”
Low levels of vitamin D in the blood are tied to an increased risk of developing multiple sclerosis.
People who have multiple sclerosis and low levels of vitamin D are more likely to have greater disability and more disease activity.
For the study, 40 people with relapsing-remitting multiple sclerosis received either 10,400 international units or 800 international units of vitamin D3 supplements per day for 6 months.
Patients with severe vitamin D deficiency were not included in the study. The current recommended daily allowance of vitamin D3 is 600 international units.
Blood tests at the start of the study and again at 3 and 6 months measured the amount of vitamin D in the blood and the response in the immune system’s T cells, which play a key role in multiple sclerosis.
While researchers are still determining the optimal level of vitamin D in the blood for people with MS, a suggested range of 40 to 60 nanograms per milliliter (ng/ml) has been proposed as a target.
Participants taking the high dose of vitamin D reached levels within the proposed target, whereas the group taking the low dose did not reach the target.
Side effects from the vitamin supplements were minor and were not different between the people taking the high dose and the people taking the low dose. One person in each group relapsed.
The people taking the high dose had a reduction in the percentage of inflammatory T cells related to MS severity, specifically IL-17+CD4+ and CD161+CD4+ cells.
When the increase in vitamin D levels in the blood over base line levels was greater than 18 ng/ml, every additional 5 ng/ml increase in vitamin D led to a 1 percent decrease in the percentage of IL-17+CD4+ T cells in the blood.
The people taking the low dose did not have any noticeable changes in the percentages of their T cell subsets.
“We hope that these changes in inflammatory T cell responses translate to a reduced severity of disease,” says Calabresi. “Other clinical trials are underway to determine if that is the case.”
Citation: Sotirchos ES, et al. (2015). Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. Neurology. DOI: 10.1212/WNL.0000000000002316.
Figure legend: This Knowridge.com image is for illustrative purposes only.